NINE HOLE PEG TEST (manual dexterity)

 

ABILHAND score (manual ability)

 

 

Timed 25-foot walk test

( for those PWAms able to walk)

 

Sloan Low Contrast Letter (visual acuity score)

 

Symbol Digit Modalities Testscore (cognition)

 

Multiple Sclerosis Impact Scale (quality of life score)

 

Neurological Fatigue Index-Multiple Sclerosis score.

 

Work Productivity and Activity Impairment Questionnaire: (General Health score)

 

MRI:

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Change over 24 months in brain volume assessed using the “Structural Image Evaluation, using Normalisation, of Atrophy” (SIENA) technique

 

Change in the total cross-sectional area of spinal cord over 24 months

 

Total number of new focal demyelinating brain lesions over 24 months

 

Total number of new hypo-intense T1 lesions over 24 months

 

Change over 24 months of the study in ventricular volume assessed using the VIENA technique.

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